Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis by Alessandro Cassini, MD, Liselotte Diaz Högberg, PhD, Diamantis Plachouras, PhD, Annalisa Quattrocchi, PhD, Ana Hoxha, MSc, Gunnar Skov Simonsen, PhD.
Conclusion: The health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.
A novel desinfection strategy to prevent surgical site infection by Katrina Brown, James Crowley, Rema Oliver, William Walsh. Surgical & Orthopedic Research Laboratory, University of New South Wales, Price of Wales Hospital, Australia
Conclusion: THOR-UVC disinfection technology successfully reduced the environmental bioburden orthopaedic operating theatres. As contaminated surfaces facilitate the transmission of pathogens, it is essential to consider UVC as an adjunct cleaning strategy for the prevention of SSI’s
Anthropological and socioeconomic factors contributing to global antimicrobial resistance: a univariate and multivariable analysis by Peter Collignon, John J Beggs, Timothy R Walsh, Sumanth Gandra and Ramanan Laxminarayan
Conclusion: This paper shows that decrease antibiotic consumption alone are not likely to be sufficient, because contagion is probably the main factor affecting antimicrobial resistance levels.
Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection) by Deverick J Anderson, Rebekah W Moehring, David J Weber, Sarah S Lewis, Luke F Chen, J Conrad Schwab, Paul Becherer, Michael Blocker, Patricia F Triplett, Lauren P Knelson, Yuliya Lokhnygina, William A Rutala, Daniel J Sexton, for the CDC Prevention Epicenters Program
Conclusion: Enhanced terminal room disinfection with UV in a targeted subset of high-risk rooms led to a decrease in hospital-wide incidence of C difficile and VRE. Enhanced disinfection overcomes limitations of standard disinfection strategies and is a potential strategy to reduce the risk of acquisition of multidrug-resistant organisms and C difficile.
The Lancet; Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study by Dr. Deverick J. Anderson, MD
Conclusion: A contaminated health-care environment is an important source for acquisition of pathogens; enhanced terminal room disinfection decreases this risk. Adding UV light to standard cleaning cut transmission of 4 resistant bacteria by 30 percent.
Conclusion: Our data demonstrated that a decrease in room contamination is associated with a decrease in subsequent patient colonization/infection. We showed that an enhanced method of room decontamination is superior to a standard method. Hospitals should consider the use of an enhanced method of room decontamination for terminal disinfection
Room Decontamination with UV Radiation by i.e. William A. Rutala, PhD
Conclusion: This UV-C device was effective in eliminating vegetative bacteria on contaminated surfaces both in the line of sight and behind objects within approximately 15 minutes and in eliminating C. difficile spores within 50 minutes.
Terminal Decontamination of Patient Rooms Using an Automated Mobile UV Light Unit by i.e. John M. Boyce, MD
Conclusion: The mobile UV-C light unit significantly reduced aerobic colony counts and C. difficile spores on contaminated surfaces in patient rooms.
Conclusion: Continuous Wave UVC Room Disinfection device is a novel, automated, and efficient environmental disinfection technology that significantly reduces C. difficile, VRE and MRSA contamination on commonly touched hospital surfaces.
Conclusion: Automated decontamination devices are able to reduce the number of organisms in places that are easily missed by or inaccessible to human cleaning. The UV radiation device requires less than 1 hour per bed (room) for a typical cycle and is easy to use. Routine use of UV radiation devices to decrease the environmental burden of pathogens is a feasible addition to current infection control and housekeeping measures and may ultimately help reduce rates of CDI among patients in hospitals and LTCFs.
Conclusion: Efficacy of UVC Irradiation in Decontamination of A.Baumannii Cells on different surfaces: “The UVC exposure resulted in >4log(CFU) reductions in viable cells for all three metal surfaces. The killing was complete because no turbidity was observed when the test coupons were incubated in tryptic soy broth. Complete killing or decontamination of inanimate surfaces may be a desirable goal in intensive care units and patient treatment facilities.” “UVC irradiation is a cost effective, easy to use, non-invasive, non-corrosive approach with no adverse environmental effects”
First UK trial of an automated UV-C room decontamination device by Nikunj Mahida.
Conclusion: The UVC Unit was easy to use and room disinfection times were relatively short. Without the need to inactivate room ventilation or smoke detectors, we were able to disinfect 3 ITU single rooms within 3 hours. This device appears to achieve significant killing of key healthcare environmental pathogens including MRSA, VRE, MRA and Aspergillus.
The cost of an outbreak by Jon Otter, PhD FRCPath Imperial College London
Conclusion: HCAI and outbreaks are expensive. This argues for ‘prevention is better than cure’. We need to have accurate, meaningful costs of outbreaks to justify investment in enhanced outbreak detection and prevention.